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Monozygotic bichorionic twinning after transfer of a single frozen/thawed embryo that has undergone quarter laser-assisted zona thinning: a case report.

Allegra A, Sammartano F, Scaglione P, Coffaro F, Marino A, Volpes A

ANDROS Day Surgery, Reproductive Medicine Unit, Via Ausonia 43/45, Palermo, I-90144, Italy.

PURPOSE: To present the occurrence of a monozygotic bichorionic twinning after the transfer of a single frozen/thawed embryo has undergone assisted zona hatching (AZH), using a non contact laser. METHODS: A 33-year-old woman who underwent single frozen embryo replacement (FER). Before transfer, the patient was treated with GnRH agonist and with substitutive therapy (estrogens and progesterone). CONCLUSIONS: We are absolutely certain that we are reporting a monozygotic bichorionic pregnancy: a single frozen/thawed embryo was transferred and no concomitant spontaneous conception was possible. Moreover, molecular biology assessment for polymorphisms confirmed clinical findings. The possibility of the occurrence of a monozygotic bichorionic twinning after the transfer of a single frozen/thawed embryo should be borne in mind and its incidence will have to be studied further.

Published 6 December 2005 in J Assist Reprod Genet, 22(11): 437-41.
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